Crospovidone Nf

Ulanqab Kema New Material Co., Ltd. is one of the most experienced manufacturers and suppliers of crospovidone nf in China. Please rest assured to wholesale high quality crospovidone nf made in China here from our factory. If you have any enquiry about free sample, please feel free to email us.

Property and Application:

Good compatibility

Crospovidone nf and a variety of organic and inorganic pharmaceutical excipients and active ingredients have very good compatibility. Solid drugs containing PVPP tablet disintegrants can use common tablet production techniques, including direct compression, It is easy to produce by spraying, drying and wet granulation.

Compressibility and adhesion

Crospovidone nf has excellent fluidity and plastic deformation, so they have excellent adhesion. This property gives good compressibility in spraying, drying, and wet granulation. Adding PVPP tablet disintegrant to the tablet, compared with commonly used starch, cellulose preparations and pectin compounds, the hardness and abrasion resistance of the tablet are not affected, and the capping of the tablet is not reduced. Crospovidone nf can also be effectively used as a tablet disintegrant in direct compression, without the use of lubricants or the addition of binders.

Capillary activity and hydration capacity

Research work has shown that PVPP as a tablet disintegrant has high capillary activity and hydration capacity, because of their large specific surface area (average 1.25 m2/g) and significant water absorption (high and rapid water absorption) , Up to 60% or more).

Swelling and disintegration

PVPP has high capillary activity, so it can quickly absorb water into the tablet. Because the internal pressure (swelling pressure) exceeds the strength of the tablet, the tablet disintegrates instantly. And because there are folded molecular chains between the crosslinks, when water or aqueous solution penetrates, they are stretched by sudden impact and forced to separate immediately. As a result of swelling, the net volume increases (approximately doubled in 5 minutes), so that tablets prepared with PVPP tablet disintegrants disintegrate immediately.

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