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Status of the inclusion of different specifications of vinylpyrrolidone polymerization in the National Pharmacopoeia.

Dosage form	Contains PVP ingredients	PVP content (% mass)	Main effect
Tablet	PVP-K30	0.5-5	Adhesion/Solubilization/Shaping
Granule	PVP-K30	0.5-5	Adhesion/Solubilization/Shaping
Coating agent	PVP-K90	0.5-2	Tablet (pill) coat/film former
capsule	PVP-K30	1-2	Help granulation/protective agent disintegrant
Co-precipitating agent	PVP-K15	--	Improve the dissolution rate
injection	PVP-K15	5-15	Solubilization/dispersion
Oral liquid	PVP-K15/PVP-K60	--	Dispersing/thickening
Taking tablets	PVP-K30/PVP-K90	2-10	Increase efficacy/decrease irritation
Disinfectant	PVP-I	--	Sterilization/disinfection/reduction of toxicity/irritation
Lozenge	PVP-K30/PVP-K60	0.5-5	Shaping/Slow Release

Taking advantage of PVP's good solubility, solubilization, physiological compatibility, bonding ability and complexing ability, etc., in the field of medicine and health, it replaces adhesives, excipients, coating agents, disintegrants, and cosolvents. , Bactericidal and disinfectant, solubilizer, slow-release agent, capsule shell, dispersion stabilizer, film-forming agent, etc. In some cases, such as the United States, Japan, etc., the dosage and effect of PVP in the medical and health field are shown in Table 6.2.

PVP was first used in drug production in my country in the 1980s. In 1985, Zhejiang Research Institute of Chemical Industry and Hangzhou Minsheng Pharmaceutical Co., Ltd. jointly developed a new type of disinfectant PVP-I with PVP as the main ingredient. Later, some manufacturers began to use it.

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