Application of PVP in pharmaceutics research and development（3）
The solubility of rosiglitazone maleate in the intestinal juice is relatively small. It is speculated that its absorption rate in the intestine will be affected by this. Therefore, it is necessary to make rosiglitazone maleate into a solid dispersion to increase its solubility. And dissolution rate. Infrared spectroscopy analysis proved that there was no chemical reaction between the two, and X-ray powder diffraction analysis indicated that it was dispersed in the carrier PVPK30 in an amorphous state. Using water-soluble materials as the carrier can greatly improve the dissolution and absorption of the drug by improving the wettability of the drug, ensuring the high dispersibility of the drug and the crystal inhibitory property of the carrier material. The author prepared solid dispersions of 1:5, 1:10, 1:15, and 1:20 (drug: PVPK30), respectively. There was no significant difference in the dissolution rate. Considering the number of excipients, a solid dispersion of 1:5 was selected.
5. Used in sustained and controlled release preparations
PVP can be used as adhesives, retarders, penetration enhancers, etc. in sustained and controlled release formulations. Experts have developed single-compartment single-layer nifedipine oral osmotic pump tablets, optimized the formulation and preparation parameters of nifedipine oral osmotic pump tablets, and determined the optimal tablet core formulation, in which PVP is 7.08% as a penetration aid.
6. PVP-I (Povidone-iodine preparations)
PVP-I (Povidone-iodine preparation) is a soluble compound formed by iodine and PVP. It is a highly efficient and spectral new fungicide. Compared with iodine, it has low volatility, good water solubility, and almost no irritation. Allergy and other advantages. At present, many products are being researched or already on the market, including various dosage forms of solutions (skin disinfectants and ophthalmic disinfectants), suppositories (vaginal suppositories, urethral suppositories, and effervescent suppositories), ointments, and paints.