Cross-linked povidone is a water-insoluble tablet disintegrant, which can quickly show high capillary activity and excellent hydration ability, with almost no tendency to gel; research shows that the size of cross-linked povidone particles has a strong influence The disintegration of antipyretic analgesic tablets, crospovidone with larger particles can disintegrate faster than smaller ones. Cross-linked povidone is a very good disintegrant. The dosage in tablets is generally 1-2%, which can achieve the disintegration effect of other commonly used ordinary disintegrants and is called a super disintegrant.
Cross-linked povidone can also be used as a dry binder, filler and excipient for tablets, capsules, and granules. The smaller particle size can reduce the markings on the side of the compressed tablet and improve the tablet’s performance. For uniformity, the usual amount is 20-80mg/tablet.
Cross-linked povidone can also be used as a dissolution accelerator. Co-evaporation technology can increase the solubility of poorly soluble drugs: firstly, the drug is adsorbed on cross-linked povidone with a suitable solvent, and then the solvent is evaporated. This technology can Obtain a faster dissolution rate.
This product is also widely used as a filter aid in the production of wine and vinegar in the food industry to remove enzymes and proteins.
Cross-linked povidone and polyphenols can form stable complexes, which can be used to refine water-soluble or alcohol-containing herbal extracts and tinctures to improve the stability of plant medicine.